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MRgFUS - MRgFUS
Oncology & Pain Management

TOMABLATE Oncology

TOMABLATE’s MR guided Focused Ultrasound technology (MRgFUS) can treat painful bone metastases from all primary cancer types, providing prompt pain relief and significant improvement in patient’s quality of life. This non-invasive treatment uses focused ultrasound waves, guided by magnetic resonance imaging (MRI), to ablate the targeted tumor, ensuring an effective treatment with minimal damage to surrounding tissue. The treatment uses no ionizing radiation.

Pain Palliation of Bone Mats

TOMABLATE uses MR guided Focused Ultrasound (MRgFUS) as a non-invasive thermal ablation technique to relieve pain caused by bone metastasis with minimum effect on the surrounding tissue. The palliative effect of MRgFUS is based on the destruction of periosteal denervation by controlled heating plus some tissue control of the tumor itself, where possible.

 The focused ultrasound energy is focused on and around the affected area, heating the region to around 65-85ºC for a few seconds. This heating causes damage to the targeted periosteum (covering of the bone) and damages the local nerve network, causing nerve denervation. Damaging the nerves means they can no longer conduct pain signals, therefore reducing the pain from this type of lesion. This process is repeated multiple times until the whole metastatic tumor is covered plus a margin around its edges. In some circumstances it can also be useful for controlling the soft tissue parts of the tumor when it’s safe to apply higher levels of energy. The goal of this treatment is to provide pain palliations from these lesions with a technique that doesn’t require ionizing radiation.

Malignent and Benign Local Bone Tumor Control

TOMABLATE uses MR guided Focused Ultrasound (MRgFUS) as a non-invasive thermal ablation technique similar to the one used to relieve pain caused by bone metastasis with minimum effect on the surrounding tissue. The palliative effect of MRgFUS is based on destruction of periosteal denervation by controlled heating plus some tissue control of the tumor itself, where possible.

 Similar in effect to treating metastatic bone lesions where energy is focused on and around the bone lesion itself; here the heating is focused onto a thermal spot ranging from 20-70mm in length and 3-10mm in diameter. Heating the focal tissue to around 65-85ºC for a few seconds results in local tissue necrosis and cell death in the treated region. A single focal application of energy is called a ‘sonication’ and a treatment comprises multiple repetitions. Sonications are repeated until the entire volume of the tumor has been treated. The effect of the treatment is evaluated immediately after the treatment by injecting a contrast agent (special dye) that shows up on MRI, indicating the extent of the treatment within the targeted region.

Osteoid osteoma

TOMABLATE uses MR guided Focused Ultrasound (MRgFUS) as a non-invasive thermal ablation technique to relieve pain caused by osteoid osteoma with minimum effect on the surrounding tissue. The palliative effect of MRgFUS is based on destruction of periosteal denervation by controlled heating.

 The focused ultrasound energy is focused on and around the osteoid osteoma bone lesion itself, heating the region to around 65-85ºC for a few seconds. This heating causes damage to the targeted periosteum (covering of the bone) and damages the local nerve network, causing nerve denervation. Damaging the nerves means they can no longer conduct pain signals, therefore reducing the pain from this type of lesion. A single application of the energy is called a ‘sonication’ and a treatment comprises multiple repetitions to cover the lesions. The goal of the treatment is to provide total pain relief from these lesions. However, one or two focally directed sonications may also be directed at the nidus of the lesion and may result in complete ablation of the lesion providing not only pain control but also soft tissue death of the lesion itself.

Facet Rhizotomy

TOMABLATEuses MR guided Focused Ultrasound (MRgFUS) as a non-invasive thermal ablation technique to relieve back pain caused by facet joint osteoarthritis with minimum effect on the surrounding tissue. The palliative effect of MRgFUS is based on destruction of periosteal denervation by controlled heating.

The focused ultrasound energy is focused onto a small area of the painful joint, thermal energy is deposited, resulting in protein denaturation at temperatures above 55ºC for one second. Heating the peri-articular tissue beyond this threshold for a few seconds, results in local tissue necrosis, which causes denervation of the nerves network around the facet joint. The focused ultrasound beam is then focused onto another facet and this new area is treated. The process is repeated until all the nerves causing the pain are destroyed.

(Last Updated: June 18, 2018)

 

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